RRT Molecule Removal Methods

SubstanceMW (Daltons)Vd (L/kg)Removal byLipophilicityProtein BindingEXTRIP recommends
N-acetyl-p-aminophenol (APAP/Paracetamol/Acetaminophen)1510.9DiffusionLowLowyes
Amatoxins (eg a-amanitin)9180.2-0.4DiffusionLowLowpending
Baclofen2140.8DiffusionLowLowyes
Barbiturates (eg phenobarbital)2320.5DiffusionModerateModerateIHD>>HP>CRRT
b-blockers: propranolol2594DiffusionHighHighno
b-blockers: atenolol2660.7DiffusionLowLowIHD
b-blockers: sotalol2722DiffusionLowLowIHD
Ca-channel blockers40921DiffusionHighHighno
Carbamazepine2360.8-1.9DiffusionHighHighIHD>HP>CRRT
Digoxin7815-7DiffusionModerateModerateno
Toxic Alcohols: Ethylene Glycol620.5-0.8DiffusionLowLowIHD>CRRT
Toxic Alcohols: Methanol320.6-0.7DiffusionLowLowIHD>CRRT
Gabapentin/pregablin171/1590.6-0.8DiffusionLowLowIHD>CRRT
Isoniazid1370.6-0.7DiffusionLowLowOnly in addition
Lithium70.6-0.9DiffusionLowLowyes
Metformin1290.6-1.2DiffusionLowLowIHD>CRRT
Methotrexate4540.6-0.8DiffusionLowHighno
Phenytoin2520.6-0.8DiffusionHighHighyes
Quinine/chloroquinehydroxychloroquine324/320/3352-5/200-800/5.5DiffusionHighHighno
Salicylates (eg aspirin)1800.1-0.2DiffusionLowHighyes
Thallium2043-8DiffusionLowLowIHD>CRRT
Theophylline1800.5-0.8DiffusionLowLowIHD>HP>CRRT
TCA (eg amitriptyline)27710-50DiffusionHighHighno
Valproic acid1440.1-0.4DiffusionHighHighIHD>HP>CRRT